منابع مشابه
On the Fluorescence Quenching of Substituted Coumarins
In the present work the effect of different concentration of halide quenchers (Cl, Br, I) on 4-methyl-5-ethoxy-7-methoxy coumarin (1) and 4-methyl-5,7-diethoxy coumarin (2) in aqueous solutions have been carried out at 20 temperature. It was observed that the fluorescence intensity of these coumarin derivatives decrease with increase in the concentration of the quenchers except Cl quencher. Fur...
متن کاملANtIMYcoBActeRIAL ActIVItY oF 4- AND 3,4-sUBstItUteD coUMARINs
The present article describes the evaluation of the in vitro activity against M. tuberculosis H37Rv of eight coumarin-derived aminoalcohols and amidoamines. Seven of the compounds display activity between 10 and 20 times higher than the classicall anti-TB drug ethambutol. The combination of coumarin scaffold with aminoalcohol fragments gave the most promising activities with MICs up to 0.32 μM.
متن کاملSpectral properties of substituted coumarins in solution and polymer matrices.
The absorption and fluorescence spectra of substituted coumarins (2-oxo-2H-chromenes) were investigated in solvents and in polymer matrices. The substitutions involved were: (1) by groups with varying electron donating ability such as CH₃, OCH₃ and N(CH₃)₂, mainly, but not exclusively, in positions 7 and (2), by either CHO or 4-PhNHCONHN=CH- in position 3. While the spectra of non-substituted c...
متن کامل4-Trifluoromethyl-substituted coumarins with large Stokes shifts: synthesis, bioconjugates, and their use in super-resolution fluorescence microscopy.
Bright and photostable fluorescent dyes with large Stokes shifts are widely used as sensors, molecular probes, and light-emitting markers in chemistry, life sciences, and optical microscopy. In this study, new 7-dialkylamino-4-trifluoromethylcoumarins have been designed for use in bioconjugation reactions and optical microscopy. Their synthesis was based on the Stille reaction of 3-chloro-4-tri...
متن کاملDiscovery of new 7-substituted-4-imidazolylmethyl coumarins and 4'-substituted-2-imidazolyl acetophenones open analogues as potent and selective inhibitors of steroid-11β-hydroxylase.
Diseases triggered by an abnormally high level of cortisol (hypercortisolism), such as the Cushing's and metabolic syndromes, could be successfully tackled by inhibitors of CYP11B1, a steroidal cytochrome P450 enzyme that catalyzes the last hydroxylation step of the cortisol biosynthesis. Structural optimization of 7-(benzyloxy)-4-(1H-imidazol-1-ylmethyl)-2H-chromen-2-one 2, a selective aromata...
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ژورنال
عنوان ژورنال: NIPPON KAGAKU KAISHI
سال: 1976
ISSN: 0369-4577,2185-0925
DOI: 10.1246/nikkashi.1976.247